TNF Superfamily Meeting 2019

TNF Superfamily Meeting 2019

ANRF provided travel grants for upcoming scientists in their postdoctoral fellowship period to attend the 17th International Conference on the TNF Superfamily. Tumor Necrosis Factor is one of the key cytokines that causes destructive inflammation in autoimmune diseases, and drugs that inhibit TNF, such as Enbrel, Humira and others, are often successful in alleviating inflammation. New breakthroughs in understanding inflammation are often presented at this conference.

The conference was held in the beautiful Asilomar Conference Center in Pacific Grove, California, from June 3rd-7th 2019.  The exciting scientific program covered full gambit of the TNF cytokines and receptors: from fundamental research to therapeutic targeting and clinical applications.  The conference was attended by leaders in the field as speakers with 127 participating scientists. In keeping with ANRF’s objectives to support young scientists, 24 travel grants were awarded to postdocs from the US and other countries attending the meeting.  The ANRF’s supported the ability of these scholars to present their results and network scientific relationships to advance research. 

The unique structural features of the tumor necrosis factor (TNF) family of ligands and receptors link these molecules to cell growth, cell survival or cell death, although some molecules can activate both inflammatory and cell death pathways, dependent on target cell types and other extrinsic stimuli. Many of the TNF molecules are expressed in cells of the immune system, which implies that they are central to autoimmune and inflammatory diseases, as well as cancer. However, their function is not limited to immune cells. Members of these molecules have been linked to an array of pathophysiologies (altered physiological processes associated with disease or injury), including cancer, neurologic, cardiovascular, pulmonary, autoimmune and metabolic diseases. drugs that inhibit TNF, such as Enbrel, Humira and others as described earlier, are often successful in alleviating inflammation. As a result, they are an attractive target for the development of new therapeutics for the treatment of these diseases and the TNF Superfamily Conference provided a stimulating programme highlighting the remarkable research being done in this area.

Congratulations to the recipients on their travel award that enabled them to attend the meeting, giving these researchers the opportunity to present their results and to advance research. 

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Article Author
Arthritis National Research Foundation

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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