For nearly two decades, researchers have been scouring the human genome for genes that promote osteoarthritis (OA) in an effort to find new targets for osteoarthritis treatments. Today, scientists suspect that OA results not from unique genes, but from “epigenetic” changes in gene expression. Epigenetics...
An estimated 30 million Americans suffer from osteoarthritis (OA), the leading cause of chronic disability in older adults. Nearly half of all adults over the age of 65 have been affected by the development of osteoarthritis, a degenerative joint disease. OA creates a painful inflammatory response...
Knee injuries are painful, debilitating and extremely common. A sudden twist of the knee can tear the cartilage that cushions and stabilizes the joint. Knee injuries often predict the development of osteoarthritis (OA). Even when an injury is surgically repaired, damage to cartilage triggers a...
When osteoarthritis (OA) strikes, pain flashes to sensory receptors, unleashing tiny electrical pulses that race up the spinal cord to the brain. Neurons, or specialized nerve cells, release chemical messengers that deliver pain signals from arthritic joints to the sensory network. Now a new generation of...
New tissue engineering techniques may completely change how we treat osteoarthritis (OA). OA is a disabling disease that gradually destroys articular cartilage, which helps bones move smoothly and easily within joints. As the cartilage layer thins, bones rub against each other, causing swelling, stiffness and...
Aging is the primary risk factor for the development of osteoarthritis (OA). Every day, more than 27 million Americans suffer from grinding bone-on-bone pain, chronic stiffness, cartilage damage and the nagging ache of degenerative joint disease. An aging America is fueling a push for more research...
Growing up, I remember doing class assignments that asked us where we envisioned our lives to be in five, ten, twenty years. Being diagnosed with rheumatoid arthritis (RA) at eighteen and having a total knee replacement at twenty-nine years old was not on my radar. My...
Osteoarthritis (OA) is a chronic degenerative joint disease that affects 27 million Americans and ultimately leads to irreversible joint damage. Over time, OA destroys the smooth layer of articular cartilage that cushions the ends of bones where they come together to form joints. As the...
In this next installment of our new #CureArthritis web series we take a look out how grant recipient Dr. Denis Evseenko is on the cusp of creating the first medication to treat Osteoarthritis. Currently, people with osteoarthritis have very few options for managing the disease and...
Finding new osteoarthritis drug targets is the focus of many researchers including the recently funded Dr. Jenna Galloway. Osteoarthritis is a degenerative disease that gradually destroys cartilage and bone. Normally, cartilage cushions the ends of bones and provides a smooth gliding surface for joint movement....