In vivo real time imaging of proteinase activity in arthritis mouse models
Koichiro Ohmura, M.D., Ph.D.
Joslin Diabetes Center (affiliated with Harvard Medical School)
Dr. Ohmura is perfecting an imaging technology with the potential to greatly benefit the diagnosis of, research on and monitoring the treatment of inflammatory arthritis. He will image the proteinases in the joints of mice with various forms of arthritis. An increase in proteinase activity is one of the initial events of joint destruction in both rheumatoid arthritis and osteoarthritis. This technology may be useful in human disease to image otherwise undetectable or changing levels of cartilage- or bone-threatening increased enzymatic activity.