Generation of antigen-specific T regulatory cells in TCR transgenic mice to prevent the collagen-induced arthritis
Dr. Zheng’s laboratory has developed the ability to induce T cells to develop strong suppressive activity ex-vivo (outside the body) and have acquired evidence from animal models that that these cells can block immune-mediated inflammation in vivo (in the body) when transferred back to the animals. The success of this project may increase the possibility that Tr cells induced ex-vivo can also be used to treat RA patients.